Ontology highlight
ABSTRACT:
SUBMITTER: Huggins P
PROVIDER: S-EPMC3166550 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Huggins P P Johnson C K CK Schoergendorfer A A Putta S S Bathke A C AC Stromberg A J AJ Voss S R SR
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110330 1
The Mexican axolotl (Ambystoma mexicanum) presents an excellent model to investigate mechanisms of brain development that are conserved among vertebrates. In particular, metamorphic changes of the brain can be induced in free-living aquatic juveniles and adults by simply adding thyroid hormone (T4) to rearing water. Whole brains were sampled from juvenile A. mexicanum that were exposed to 0, 8, and 18 days of 50 nM T4, and these were used to isolate RNA and make normalized cDNA libraries for 454 ...[more]