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Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia.


ABSTRACT: Outcome after unrelated donor bone marrow (BM) transplantation for severe aplastic anemia (SAA) has improved, with survival rates now approximately 75%. Increasing use of peripheral blood stem and progenitor cells (PBPCs) instead of BM as a graft source prompted us to compare outcomes of PBPC and BM transplantation for SAA. We studied 296 patients receiving either BM (n = 225) or PBPC (n = 71) from unrelated donors matched at human leukocyte antigen-A, -B, -C, -DRB1. Hematopoietic recovery was similar after PBPC and BM transplantation. Grade 2 to 4 acute graft-versus-host disease risks were higher after transplantation of PBPC compared with BM (hazard ratio = 1.68, P = .02; 48% vs 31%). Chronic graft-versus-host disease risks were not significantly different after adjusting for age at transplantation (hazard ratio = 1.39, P = .14). Mortality risks, independent of age, were higher after PBPC compared with BM transplantation (hazard ratio = 1.62, P = .04; 76% vs 61%). These data indicate that BM is the preferred graft source for unrelated donor transplantation in SAA.

SUBMITTER: Eapen M 

PROVIDER: S-EPMC3167362 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Effect of stem cell source on outcomes after unrelated donor transplantation in severe aplastic anemia.

Eapen Mary M   Le Rademacher Jennifer J   Antin Joseph H JH   Champlin Richard E RE   Carreras Jeanette J   Fay Joseph J   Passweg Jakob R JR   Tolar Jakub J   Horowitz Mary M MM   Marsh Judith C W JC   Deeg H Joachim HJ  

Blood 20110615 9


Outcome after unrelated donor bone marrow (BM) transplantation for severe aplastic anemia (SAA) has improved, with survival rates now approximately 75%. Increasing use of peripheral blood stem and progenitor cells (PBPCs) instead of BM as a graft source prompted us to compare outcomes of PBPC and BM transplantation for SAA. We studied 296 patients receiving either BM (n = 225) or PBPC (n = 71) from unrelated donors matched at human leukocyte antigen-A, -B, -C, -DRB1. Hematopoietic recovery was s  ...[more]

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