Ontology highlight
ABSTRACT:
SUBMITTER: Bussotti G
PROVIDER: S-EPMC3167602 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Bussotti Giovanni G Raineri Emanuele E Erb Ionas I Zytnicki Matthias M Wilm Andreas A Beaudoing Emmanuel E Bucher Philipp P Notredame Cedric C
Nucleic acids research 20110530 16
We present and validate BlastR, a method for efficiently and accurately searching non-coding RNAs. Our approach relies on the comparison of di-nucleotides using BlosumR, a new log-odd substitution matrix. In order to use BlosumR for comparison, we recoded RNA sequences into protein-like sequences. We then showed that BlosumR can be used along with the BlastP algorithm in order to search non-coding RNA sequences. Using Rfam as a gold standard, we benchmarked this approach and show BlastR to be mo ...[more]