Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
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ABSTRACT:
SUBMITTER: Bucay N
PROVIDER: S-EPMC316769 | biostudies-literature | 1998 May
REPOSITORIES: biostudies-literature
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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay N N Sarosi I I Dunstan C R CR Morony S S Tarpley J J Capparelli C C Scully S S Tan H L HL Xu W W Lacey D L DL Boyle W J WJ Simonet W S WS
Genes & development 19980501 9
Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent and adult OPG-/- mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone porosity, marked thinning of the parietal bones of the skull, and a high incidence of fractures. These findings demonstrate that OPG is a critical regulator of postnatal bone mass. Unexpectedly, OPG- ...[more]
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