P53-mediated apoptosis is attenuated in Werner syndrome cells.
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ABSTRACT:
SUBMITTER: Spillare EA
PROVIDER: S-EPMC316776 | biostudies-literature | 1999 Jun
REPOSITORIES: biostudies-literature
Publications
p53-mediated apoptosis is attenuated in Werner syndrome cells.
Spillare E A EA Robles A I AI Wang X W XW Shen J C JC Yu C E CE Schellenberg G D GD Harris C C CC
Genes & development 19990601 11
The WRN DNA helicase is a member of the DExH-containing DNA helicase superfamily that includes XPB, XPD, and BLM. Mutations in WRN are found in patients with the premature aging and cancer susceptibility syndrome known as Werner syndrome (WS). p53 binds to the WRN protein in vivo and in vitro through its carboxyl terminus. WS fibroblasts have an attenuated p53- mediated apoptotic response, and this deficiency can be rescued by expression of wild-type WRN. These data support the hypothesis that p ...[more]
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