Ontology highlight
ABSTRACT:
SUBMITTER: Lindquist S
PROVIDER: S-EPMC3167820 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Lindquist Sabine S Karitkina Diana D Langnaese Kristina K Posevitz-Fejfar Anita A Schraven Burkhart B Xavier Ramnik R Seed Brian B Lindquist Jonathan A JA
PloS one 20110906 9
Src family kinases (SFK) control multiple processes during brain development and function. We show here that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain. The timing and localization of PAG expression overlap with Fyn and Src, both of which we find associated to PAG. We demonstrate in newborn (P1) mice that PAG negatively regulates Src family kinases (SFK). P1 Pag1(-/-) mouse brains show decreased re ...[more]