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Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones.

ABSTRACT: Photolysis of aryl azides to give nitrenes, and their subsequent rearrangement in the presence of water to give 3H-azepinones, is performed in continuous flow in a photoreactor constructed of fluorinated ethylene polymer (FEP) tubing. Fine tuning of the reaction conditions using the flow reactor allowed minimization of secondary photochemical reactions.

SUBMITTER: Bou-Hamdan FR

PROVIDER: S-EPMC3167900 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones.

Bou-Hamdan Farhan R FR Lévesque François F O'Brien Alexander G AG Seeberger Peter H PH

Beilstein journal of organic chemistry 20110817

Photolysis of aryl azides to give nitrenes, and their subsequent rearrangement in the presence of water to give 3H-azepinones, is performed in continuous flow in a photoreactor constructed of fluorinated ethylene polymer (FEP) tubing. Fine tuning of the reaction conditions using the flow reactor allowed minimization of secondary photochemical reactions. ...[more]

PMID: 21915216

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