Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses.
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ABSTRACT:
SUBMITTER: da Silva AC
PROVIDER: S-EPMC3168187 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Spi2 gene polymorphism is not associated with recurrent airway obstruction and inflammatory airway disease in thoroughbred horses.
da Silva Aline Correa AC Brass Karin Erica KE da Silva Loreto Elgion E Vinocur Myriam Elizabeth ME Pozzobon Ricardo R da Silva Azevedo Marcos M
Genetics and molecular biology 20110701 3
The aim was to detect the presence of polymorphisms at exons 1, 2, 3 and 4 of the Spi2 gene, and evaluate a possible association between them and recurrent airway obstruction (RAO) or inflammatory airway disease (IAD) in thoroughbred horses, through single-strand conformational-polymorphism (SSCP) screening. Although polymorphism was not detected in exons 1, 2 and 3, three alleles and six genotypes were identified in exon 4. The frequencies of allele A (0.6388) and genotype AA (0.3888) were high ...[more]
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