Ontology highlight
ABSTRACT:
SUBMITTER: Otsuka H
PROVIDER: S-EPMC316870 | biostudies-literature | 1998 Jun
REPOSITORIES: biostudies-literature
Otsuka H H Van Haastert P J PJ
Genes & development 19980601 11
Dictyostelium development is induced by starvation. The adenylyl cyclase gene ACA is one of the first genes expressed upon starvation. ACA produces extracellular cAMP that induces chemotaxis, aggregation, and differentiation in neighboring cells. Using insertional mutagenesis we have isolated a mutant that does not aggregate upon starvation but is rescued by adding extracellular cAMP. Sequencing of the mutated locus revealed a new gene, DdMYB2, whose product contains three Myb repeats, the DNA-b ...[more]