Versican degradation and vascular disease.
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ABSTRACT:
SUBMITTER: Kenagy RD
PROVIDER: S-EPMC3169384 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Publications
Versican degradation and vascular disease.
Kenagy Richard D RD Plaas Anna H AH Wight Thomas N TN
Trends in cardiovascular medicine 20060801 6
Versican is an abundant proteoglycan in the blood vessel wall that is increased after vascular injury and accumulates in advanced atherosclerotic plaques. Versican is a large molecule with domains that mediate binding to cytokines, enzymes, lipoproteins, other extracellular matrix molecules, and signaling receptors. There is evidence that versican exists in the normal, as well as the diseased, vessel wall as discrete fragments, which represent these functional domains. We review the literature o ...[more]
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