A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
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ABSTRACT:
SUBMITTER: Nicholson G
PROVIDER: S-EPMC3169529 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
Nicholson George G Rantalainen Mattias M Li Jia V JV Maher Anthony D AD Malmodin Daniel D Ahmadi Kourosh R KR Faber Johan H JH Barrett Amy A Min Josine L JL Rayner N William NW Toft Henrik H Krestyaninova Maria M Viksna Juris J Neogi Sudeshna Guha SG Dumas Marc-Emmanuel ME Sarkans Ugis U Donnelly Peter P Illig Thomas T Adamski Jerzy J Suhre Karsten K Allen Maxine M Zondervan Krina T KT Spector Tim D TD Nicholson Jeremy K JK Lindon John C JC Baunsgaard Dorrit D Holmes Elaine E McCarthy Mark I MI Holmes Chris C CC
PLoS genetics 20110908 9
We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by (1)H NMR and tested for association with gen ...[more]
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