Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves A
PROVIDER: S-EPMC3169550 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Goncalves Adriana A Bürckstümmer Tilmann T Dixit Evelyn E Scheicher Ruth R Górna Maria W MW Karayel Evren E Sugar Cristina C Stukalov Alexey A Berg Tiina T Kralovics Robert R Planyavsky Melanie M Bennett Keiryn L KL Colinge Jacques J Superti-Furga Giulio G
PloS one 20110908 9
TANK-binding kinase 1 (TBK1) and inducible IκB-kinase (IKK-i) are central regulators of type-I interferon induction. They are associated with three adaptor proteins called TANK, Sintbad (or TBKBP1) and NAP1 (or TBKBP2, AZI2) whose functional relationship to TBK1 and IKK-i is poorly understood. We performed a systematic affinity purification-mass spectrometry approach to derive a comprehensive TBK1/IKK-i molecular network. The most salient feature of the network is the mutual exclusive interactio ...[more]