Ontology highlight
ABSTRACT:
SUBMITTER: Mormino EC
PROVIDER: S-EPMC3169663 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Mormino Elizabeth C EC Smiljic Andre A Hayenga Amynta O AO Onami Susan H SH Greicius Michael D MD Rabinovici Gil D GD Janabi Mustafa M Baker Suzanne L SL Yen Irene V IV Madison Cindee M CM Miller Bruce L BL Jagust William J WJ
Cerebral cortex (New York, N.Y. : 1991) 20110307 10
Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Aβ deposition as detected with Pittsburgh compound-B positron emission tomography (PIB-PET) imaging shows substantial spatial overlap with the default mode network (DMN), a group of brain regions that typically deactivates during externally driven cognitive tasks. In this study, we show that DMN functional connectivity (FC ...[more]