Ontology highlight
ABSTRACT:
SUBMITTER: Bearden CE
PROVIDER: S-EPMC3169664 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Bearden Carrie E CE van Erp Theo G M TG Dutton Rebecca A RA Boyle Christina C Madsen Sarah S Luders Eileen E Kieseppa Tuula T Tuulio-Henriksson Annamari A Huttunen Matti M Partonen Timo T Kaprio Jaakko J Lönnqvist Jouko J Thompson Paul M PM Cannon Tyrone D TD
Cerebral cortex (New York, N.Y. : 1991) 20110307 10
Callosal volume reduction has been observed in patients with bipolar disorder, but whether these deficits reflect genetic vulnerability to the illness remains unresolved. Here, we used computational methods to map corpus callosum abnormalities in a population-based sample of twin pairs discordant for bipolar disorder. Twenty-one probands with bipolar I disorder (mean age 44.4 ± 7.5 years; 48% female), 19 of their non-bipolar co-twins, and 34 demographically matched control twin individuals under ...[more]