Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC3169724 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Liu Pixu P Cheng Hailing H Santiago Stephanie S Raeder Maria M Zhang Fan F Isabella Adam A Yang Janet J Semaan Derek J DJ Chen Changzhong C Fox Edward A EA Gray Nathanael S NS Monahan John J Schlegel Robert R Beroukhim Rameen R Mills Gordon B GB Zhao Jean J JJ
Nature medicine 20110807 9
PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy, making phosphatidylinositol 3-kinase (PI3K) a target for cancer therapy. Despite the promise of targeted therapy, resistance often develops, leading to treatment failure. To elucidate mechanisms of resistance to PI3K-targeted therapy, we constructed a mouse model of breast cancer conditionally expressing human PIK3CA(H1047R). Notably, most PIK3CA(H1047R)-driven mammary tumors recurred after PIK3CA(H1047R) inactiv ...[more]