Ontology highlight
ABSTRACT:
SUBMITTER: Yavuzer U
PROVIDER: S-EPMC317006 | biostudies-literature | 1998 Jul
REPOSITORIES: biostudies-literature
Yavuzer U U Smith G C GC Bliss T T Werner D D Jackson S P SP
Genes & development 19980701 14
DNA-dependent protein kinase (DNA-PK), which is involved in DNA double-strand break repair and V(D)J recombination, is comprised of a DNA-targeting component termed Ku and an approximately 465-kD catalytic subunit, DNA-PKcs. Although DNA-PK phosphorylates proteins in the presence of DSBs or other discontinuities in the DNA double helix in vitro, the possibility exists that it is also activated in other circumstances via its association with additional proteins. Here, through use of the yeast two ...[more]