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Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis.

ABSTRACT: The performance of the ThalesNano H-Cube(®), a commercial packed bed flow hydrogenator, was evaluated in the context of small scale reaction screening and optimization. A model reaction, the reduction of styrene to ethylbenzene through a 10% Pd/C catalyst bed, was used to examine performance at various pressure settings, over sequential runs, and with commercial catalyst cartridges. In addition, the consistency of the hydrogen flow was indirectly measured by in-line UV spectroscopy. Finally, system contamination due to catalyst leaching, and the resolution of this issue, is described. The impact of these factors on the run-to-run reproducibility of the H-Cube(®) reactor for screening and reaction optimization is discussed.

SUBMITTER: Bryan MC

PROVIDER: S-EPMC3170201 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Evaluation of a commercial packed bed flow hydrogenator for reaction screening, optimization, and synthesis.

Bryan Marian C MC Wernick David D Hein Christopher D CD Petersen James V JV Eschelbach John W JW Doherty Elizabeth M EM

Beilstein journal of organic chemistry 20110822

The performance of the ThalesNano H-Cube(®), a commercial packed bed flow hydrogenator, was evaluated in the context of small scale reaction screening and optimization. A model reaction, the reduction of styrene to ethylbenzene through a 10% Pd/C catalyst bed, was used to examine performance at various pressure settings, over sequential runs, and with commercial catalyst cartridges. In addition, the consistency of the hydrogen flow was indirectly measured by in-line UV spectroscopy. Finally, sys ...[more]

PMID: 21915219

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