Ontology highlight
ABSTRACT:
SUBMITTER: Croix JA
PROVIDER: S-EPMC3170330 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Croix Jennifer A JA Carbonero Franck F Nava Gerardo M GM Russell Mark M Greenberg Eugene E Gaskins H Rex HR
PloS one 20110909 9
The colonic mucus layer is comprised primarily of acidomucins, which provide viscous properties and can be broadly classified into sialomucins or sulfomucins based on the presence of terminating sialic acid or sulfate groups. Differences in acidomucin chemotypes have been observed in diseases such as colorectal cancer and inflammatory bowel disease, and variation in sialo- and sulfomucin content may influence microbial colonization. For example, sulfate derived from sulfomucin degradation may pr ...[more]