Chondrogenic and gliogenic subpopulations of neural crest play distinct roles during the assembly of epibranchial ganglia.

ABSTRACT: In vertebrates, the sensory neurons of the epibranchial (EB) ganglia transmit somatosensory signals from the periphery to the CNS. These ganglia are formed during embryogenesis by the convergence and condensation of two distinct populations of precursors: placode-derived neuroblasts and neural crest- (NC) derived glial precursors. In addition to the gliogenic crest, chondrogenic NC migrates into the pharyngeal arches, which lie in close proximity to the EB placodes and ganglia. Here, we examine the respective roles of these two distinct NC-derived populations during development of the EB ganglia using zebrafish morphant and mutants that lack one or both of these NC populations. Our analyses of mutant and morphant zebrafish that exhibit deficiencies in chondrogenic NC at early stages reveal

SUBMITTER: Culbertson MD 

PROVIDER: S-EPMC3170370 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature