Ontology highlight
ABSTRACT:
SUBMITTER: Gittis AH
PROVIDER: S-EPMC3170520 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Gittis Aryn H AH Hang Giao B GB LaDow Eva S ES Shoenfeld Liza R LR Atallah Bassam V BV Finkbeiner Steven S Kreitzer Anatol C AC
Neuron 20110901 5
In Parkinson's disease (PD), dopamine depletion alters neuronal activity in the direct and indirect pathways and leads to increased synchrony in the basal ganglia network. However, the origins of these changes remain elusive. Because GABAergic interneurons regulate activity of projection neurons and promote neuronal synchrony, we recorded from pairs of striatal fast-spiking (FS) interneurons and direct- or indirect-pathway MSNs after dopamine depletion with 6-OHDA. Synaptic properties of FS-MSN ...[more]