Ontology highlight
ABSTRACT:
SUBMITTER: Bergmann C
PROVIDER: S-EPMC3170603 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Bergmann Christoph C Bachmann Hagen S HS Bankfalvi Agnes A Lotfi Ramin R Pütter Carolin C Wild Clarissa A CA Schuler Patrick J PJ Greve Jens J Hoffmann Thomas K TK Lang Stephan S Scherag André A Lehnerdt Götz F GF
Journal of translational medicine 20110821
<h4>Background</h4>Chronic inflammation plays an important role in head and neck squamous cell carcinomas (HNSCC). This study addresses the impact of two single nucleotide polymorphisms (SNP) Asp299Gly and Thr399Ile of the toll-like receptor (TLR) 4 gene on the clinical outcome while accounting for the influence of adjuvant systemic therapy in a large cohort of HNSCC patients.<h4>Methods</h4>Genotype analysis was done using DNA from tissue samples from 188 patients with HNSCC; TLR4 protein expre ...[more]