Ontology highlight
ABSTRACT:
SUBMITTER: Sieburth DS
PROVIDER: S-EPMC317062 | biostudies-literature | 1999 Oct
REPOSITORIES: biostudies-literature
Sieburth D S DS Sundaram M M Howard R M RM Han M M
Genes & development 19991001 19
We describe evidence that a regulatory B subunit of protein phosphatase 2A (PP2A) positively regulates an RTK-Ras-MAP kinase signaling cascade during Caenorhabditis elegans vulval induction. Although reduction of sur-6 PP2A-B function causes few vulval induction defects in an otherwise wild-type background, sur-6 PP2A-B mutations suppress the Multivulva phenotype of an activated ras mutation and enhance the Vulvaless phenotype of mutations in lin-45 raf, sur-8, or mpk-1. Double mutant analysis s ...[more]