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Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity.

ABSTRACT: We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

SUBMITTER: Tong S

PROVIDER: S-EPMC3170660 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity.

Tong Sheng S Hou Sijian S Zheng Zhilan Z Zhou Jun J Bao Gang G

Nano letters 20101101 11

We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications. ...[more]

PMID: 20939602

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Project description:This SuperSeries is composed of the SubSeries listed below.

2018-01-05 | GSE93188 | GEO

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