Ontology highlight
ABSTRACT:
SUBMITTER: Chapman RS
PROVIDER: S-EPMC317074 | biostudies-literature | 1999 Oct
REPOSITORIES: biostudies-literature
Chapman R S RS Lourenco P C PC Tonner E E Flint D J DJ Selbert S S Takeda K K Akira S S Clarke A R AR Watson C J CJ
Genes & development 19991001 19
Mammary gland involution is characterized by extensive apoptosis of the epithelial cells. At the onset of involution, Stat3 is specifically activated. To address the function of this signaling molecule in mammary epithelial apoptosis, we have generated a conditional knockout of Stat3 using the Cre-lox recombination system. Following weaning, a decrease in apoptosis and a dramatic delay of involution occurred in Stat3 null mammary tissue. Involution is normally associated with a significant incre ...[more]