Ontology highlight
ABSTRACT:
SUBMITTER: Jiang J
PROVIDER: S-EPMC3171134 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Jiang Jianfei J Maeda Akihiro A Ji Jing J Baty Catherine J CJ Watkins Simon C SC Greenberger Joel S JS Kagan Valerian E VE
Biochemical and biophysical research communications 20110722 1
Reactive oxygen species (ROS) are said to participate in the autophagy signaling. Supporting evidence is obscured by interference of autophagy and apoptosis, whereby the latter heavily relies on ROS signaling. To dissect autophagy from apoptosis we knocked down expression of cytochrome c, the key component of mitochondria-dependent apoptosis, in HeLa cells using shRNA. In cytochrome c deficient HeLa1.2 cells, electron transport was compromised due to the lack of electron shuttle between mitochon ...[more]