Ontology highlight
ABSTRACT:
SUBMITTER: Moreau K
PROVIDER: S-EPMC3171170 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Moreau Kevin K Ravikumar Brinda B Renna Maurizio M Puri Claudia C Rubinsztein David C DC
Cell 20110701 2
Autophagy is a catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membraned autophagosomes. Autophagosomes are formed by the elongation and fusion of phagophores, which can be derived from preautophagosomal structures coming from the plasma membrane and other sites like the endoplasmic reticulum and mitochondria. The mechanisms by which preautophagosomal structures elongate their membranes and mature toward fully formed autophagosomes still remain unknow ...[more]