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Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli.

ABSTRACT: Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry.

SUBMITTER: Roitman MF 

PROVIDER: S-EPMC3171188 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli.

Roitman Mitchell F MF   Wheeler Robert A RA   Wightman R Mark RM   Carelli Regina M RM  

Nature neuroscience 20081102 12

Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of dopamine and metabolic activity within milliseconds in the nucleus accumbens. This rapid encoding may serve to guide ongoing behavioral responses and promote plastic changes in underlying circuitry. ...[more]

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