Ontology highlight
ABSTRACT:
SUBMITTER: Gokhale A
PROVIDER: S-EPMC3171192 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20110714 15
Cell adhesion molecule CD2 and its ligand CD58 provide good examples of protein-protein interactions in cells that participate in the immune response. To modulate the cell adhesion interaction, peptides were designed from the discontinuous epitopes of the β-strand region of CD2 protein. The two strands were linked by a peptide bond. β-Strands in the peptides were nucleated by inserting a β-sheet-inducing (D)-Pro-Pro sequence or a dibenzofuran (DBF) turn mimetic with key amino acid sequences from ...[more]