Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez D
PROVIDER: S-EPMC3171608 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Rodriguez Delany D Ramesh Chinnasamy C Henson Lauren H LH Wilmeth Lori L Bryant Bj K BK Kadavakollu Samuel S Hirsch Rebecca R Montoya Johnelle J Howell Porsha R PR George Jon M JM Alexander David D Johnson Dennis L DL Arterburn Jeffrey B JB Shuster Charles B CB
Bioorganic & medicinal chemistry 20110730 18
Assembly of a bipolar mitotic spindle requires the action of class 5 kinesins, and inhibition or depletion of this motor results in mitotic arrest and apoptosis. S-Trityl-l-cysteine is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP) that has generated considerable interest due to its anti-cancer properties, however, poor pharmacological properties have limited the use of this compound. We have modified the triphenylmethyl and cysteine groups, guided by biochemical and cell-ba ...[more]