Metacaspases.
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ABSTRACT:
SUBMITTER: Tsiatsiani L
PROVIDER: S-EPMC3172103 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Metacaspases.
Tsiatsiani L L Van Breusegem F F Gallois P P Zavialov A A Lam E E Bozhkov P V PV
Cell death and differentiation 20110520 8
Metacaspases are cysteine-dependent proteases found in protozoa, fungi and plants and are distantly related to metazoan caspases. Although metacaspases share structural properties with those of caspases, they lack Asp specificity and cleave their targets after Arg or Lys residues. Studies performed over the past 10 years have demonstrated that metacaspases are multifunctional proteases essential for normal physiology of non-metazoan organisms. This article provides a comprehensive overview of th ...[more]
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