Ontology highlight
ABSTRACT:
SUBMITTER: Szu PH
PROVIDER: S-EPMC3172819 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Chemistry & biology 20110801 8
The pentadecaketide fredericamycin has the longest carbon chain backbone among polycyclic aromatic polyketide antibiotics whose biosynthetic genes have been sequenced. This backbone is synthesized by the bimodular fdm polyketide synthase (PKS). Here, we demonstrate that the bimodular fdm PKS as well as its elongation module alone synthesize undecaketides and dodecaketides. Thus, unlike other homologs, the fdm ketosynthase-chain length factor (KS-CLF) heterodimer does not exclusively control the ...[more]