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Fatty acid induced remodeling within the human liver fatty acid-binding protein.

ABSTRACT: We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling, where the first palmitate ingress creates the atomic environment for placement of the second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP.

SUBMITTER: Sharma A 

PROVIDER: S-EPMC3173104 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Fatty acid induced remodeling within the human liver fatty acid-binding protein.

Sharma Ashwani A   Sharma Amit A  

The Journal of biological chemistry 20110708 36

We crystallized human liver fatty acid-binding protein (LFABP) in apo, holo, and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry, and docking within LFABP support a heads-in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling, where the first palmitate ingress creates the atomic environment for placement of the second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFA  ...[more]

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