Ontology highlight
ABSTRACT:
SUBMITTER: Mulepati S
PROVIDER: S-EPMC3173111 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20110720 36
RNA transcribed from clustered regularly interspaced short palindromic repeats (CRISPRs) protects many prokaryotes from invasion by foreign DNA such as viruses, conjugative plasmids, and transposable elements. Cas3 (CRISPR-associated protein 3) is essential for this CRISPR protection and is thought to mediate cleavage of the foreign DNA through its N-terminal histidine-aspartate (HD) domain. We report here the 1.8 Å crystal structure of the HD domain of Cas3 from Thermus thermophilus HB8. Struct ...[more]