Ontology highlight
ABSTRACT:
SUBMITTER: Yang R
PROVIDER: S-EPMC3173121 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Yang Rong R Fredman Gabrielle G Krishnamoorthy Sriram S Agrawal Nitin N Irimia Daniel D Piomelli Daniele D Serhan Charles N CN
The Journal of biological chemistry 20110712 36
Neuroinflammation and traumatic brain injury involve activation of inflammatory cells and production of local pro-inflammatory mediators that can amplify tissue damage. Using LC-UV-MS-MS-based lipidomics in tandem with functional screening at the single-cell level in microfluidic chambers, we identified a series of novel bioactive oxygenated docosahexaenoyl ethanolamide- (DHEA) derived products that regulated leukocyte motility. These included 10,17-dihydroxydocosahexaenoyl ethanolamide (10,17-d ...[more]