Ontology highlight
ABSTRACT:
SUBMITTER: Lee HW
PROVIDER: S-EPMC3173141 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Lee Hyun-Wook HW Dominy Brian N BN Cao Weiguo W
The Journal of biological chemistry 20110603 36
DNA glycosylases play a major role in the repair of deaminated DNA damage. Previous investigations identified five families within the uracil-DNA glycosylase (UDG) superfamily. All enzymes within the superfamily studied thus far exhibit uracil-DNA glycosylase activity. Here we identify a new class of DNA glycosylases in the UDG superfamily that lacks UDG activity. Instead, these enzymes act as hypoxanthine-DNA glycosylases in vitro and in vivo. Molecular modeling and structure-guided mutational ...[more]