Synthesis of cyclic enones via direct palladium-catalyzed aerobic dehydrogenation of ketones.

ABSTRACT: ?,?-Unsaturated carbonyl compounds are versatile intermediates in the synthesis of pharmaceuticals and biologically active compounds. Here, we report the discovery and application of Pd(DMSO)(2)(TFA)(2) as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the corresponding enones, using O(2) as the oxidant. The substrate scope includes heterocyclic ketones and several natural-product precursors.

SUBMITTER: Diao T 

PROVIDER: S-EPMC3173566 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature