Ontology highlight
ABSTRACT:
SUBMITTER: Medina DL
PROVIDER: S-EPMC3173716 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Developmental cell 20110901 3
Lysosomes are cellular organelles primarily involved in degradation and recycling processes. During lysosomal exocytosis, a Ca²⁺-regulated process, lysosomes are docked to the cell surface and fuse with the plasma membrane (PM), emptying their content outside the cell. This process has an important role in secretion and PM repair. Here we show that the transcription factor EB (TFEB) regulates lysosomal exocytosis. TFEB increases the pool of lysosomes in the proximity of the PM and promotes their ...[more]