Ontology highlight
ABSTRACT:
SUBMITTER: Ambrosi E
PROVIDER: S-EPMC3174058 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Ambrosi Emmanuele E Capaldi Stefano S Bovi Michele M Saccomani Gianmaria G Perduca Massimiliano M Monaco Hugo L HL
The Biochemical journal 20110901 2
The SOUL protein is known to induce apoptosis by provoking the mitochondrial permeability transition, and a sequence homologous with the BH3 (Bcl-2 homology 3) domains has recently been identified in the protein, thus making it a potential new member of the BH3-only protein family. In the present study, we provide NMR, SPR (surface plasmon resonance) and crystallographic evidence that a peptide spanning residues 147-172 in SOUL interacts with the anti-apoptotic protein Bcl-xL. We have crystalliz ...[more]