Ontology highlight
ABSTRACT:
SUBMITTER: Heaphy CM
PROVIDER: S-EPMC3174141 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Heaphy Christopher M CM de Wilde Roeland F RF Jiao Yuchen Y Klein Alison P AP Edil Barish H BH Shi Chanjuan C Bettegowda Chetan C Rodriguez Fausto J FJ Eberhart Charles G CG Hebbar Sachidanand S Offerhaus G Johan GJ McLendon Roger R Rasheed B Ahmed BA He Yiping Y Yan Hai H Bigner Darell D DD Oba-Shinjo Sueli Mieko SM Marie Suely Kazue Nagahashi SK Riggins Gregory J GJ Kinzler Kenneth W KW Vogelstein Bert B Hruban Ralph H RH Maitra Anirban A Papadopoulos Nickolas N Meeker Alan K AK
Science (New York, N.Y.) 20110630 6041
The proteins encoded by ATRX and DAXX participate in chromatin remodeling at telomeres and other genomic sites. Because inactivating mutations of these genes are common in human pancreatic neuroendocrine tumors (PanNETs), we examined the telomere status of these tumors. We found that 61% of PanNETs displayed abnormal telomeres that are characteristic of a telomerase-independent telomere maintenance mechanism termed ALT (alternative lengthening of telomeres). All of the PanNETs exhibiting these a ...[more]