Hysteretic behavior of proprotein convertase 1/3 (PC1/3).
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ABSTRACT:
SUBMITTER: Icimoto MY
PROVIDER: S-EPMC3174183 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Hysteretic behavior of proprotein convertase 1/3 (PC1/3).
Icimoto Marcelo Y MY Barros Nilana M NM Ferreira Juliana C JC Marcondes Marcelo F MF Andrade Douglas D Machado Mauricio F MF Juliano Maria A MA Júdice Wagner A WA Juliano Luiz L Oliveira Vitor V
PloS one 20110915 9
The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes. The PC1/3 is a pivotal enzyme of this family that participates in the proteolytic maturation of prohormones and neuropeptides inside the regulated secretory pathway. In this paper we demonstrate that mouse proprotein convertase 1/3 (mPC1/3) has a lag phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme fo ...[more]
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