Tuning arousal with optogenetic modulation of locus coeruleus neurons.
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ABSTRACT:
SUBMITTER: Carter ME
PROVIDER: S-EPMC3174240 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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Tuning arousal with optogenetic modulation of locus coeruleus neurons.
Carter Matthew E ME Yizhar Ofer O Chikahisa Sachiko S Nguyen Hieu H Adamantidis Antoine A Nishino Seiji S Deisseroth Karl K de Lecea Luis L
Nature neuroscience 20101031 12
Neural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness and arousal. However, it is unclear whether tonic or phasic activity in these neurons is necessary or sufficient to induce transitions between behavioral states and to promote long-term arousal. Using optogenetic tools in mice, we found that there is a frequency-dependent, causal relationship among locus coeruleus firing, cortical activity, sleep-to-wake transitions and general locomotor arousal. We also ...[more]
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