Functional characterization of bacterial sRNAs using a network biology approach.
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ABSTRACT:
SUBMITTER: Modi SR
PROVIDER: S-EPMC3174649 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Functional characterization of bacterial sRNAs using a network biology approach.
Modi Sheetal R SR Camacho Diogo M DM Kohanski Michael A MA Walker Graham C GC Collins James J JJ
Proceedings of the National Academy of Sciences of the United States of America 20110829 37
Small RNAs (sRNAs) are important components of posttranscriptional regulation. These molecules are prevalent in bacterial and eukaryotic organisms, and involved in a variety of responses to environmental stresses. The functional characterization of sRNAs is challenging and requires highly focused and extensive experimental procedures. Here, using a network biology approach and a compendium of gene expression profiles, we predict functional roles and regulatory interactions for sRNAs in Escherich ...[more]
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