Ontology highlight
ABSTRACT:
SUBMITTER: Ranwez V
PROVIDER: S-EPMC3174933 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20110916 9
Until now the most efficient solution to align nucleotide sequences containing open reading frames was to use indirect procedures that align amino acid translation before reporting the inferred gap positions at the codon level. There are two important pitfalls with this approach. Firstly, any premature stop codon impedes using such a strategy. Secondly, each sequence is translated with the same reading frame from beginning to end, so that the presence of a single additional nucleotide leads to b ...[more]