Ontology highlight
ABSTRACT:
SUBMITTER: Guttman M
PROVIDER: S-EPMC3175327 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Guttman Mitchell M Donaghey Julie J Carey Bryce W BW Garber Manuel M Grenier Jennifer K JK Munson Glen G Young Geneva G Lucas Anne Bergstrom AB Ach Robert R Bruhn Laurakay L Yang Xiaoping X Amit Ido I Meissner Alexander A Regev Aviv A Rinn John L JL Root David E DE Lander Eric S ES
Nature 20110828 7364
Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in mammals, few have been functionally characterized, leading to debate about their biological role. To address this, we performed loss-of-function studies on most lincRNAs expressed in mouse embryonic stem (ES) cells and characterized the effects on gene expression. Here we show that knockdown of lincRNAs has major consequences on gene expression patterns, comparable to knockdown of well-known ES cell regulat ...[more]