Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC3175783 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Zhang Qian Q Wang Hongyi H Kantekure Kanchan K Paterson Jennifer C JC Liu Xiaobin X Schaffer Andras A Paulos Chrystal C Milone Michael C MC Odum Niels N Turner Suzanne S Marafioti Teresa T Wasik Mariusz A MA
Blood 20110715 11
Here we report that T-cell lymphoma cells carrying the NPM-ALK fusion protein (ALK(+) TCL) frequently express the cell-stimulatory receptor ICOS. ICOS expression in ALK(+) TCL is moderate and strictly dependent on the expression and enzymatic activity of NPM-ALK. NPM-ALK induces ICOS expression via STAT3, which triggers the transcriptional activity of the ICOS gene promoter. In addition, STAT3 suppresses the expression of miR-219 that, in turn, selectively inhibits ICOS expression. ALK(+) TCL ce ...[more]