Dataset Information
No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE.
Ontology highlight
ABSTRACT: Background
Epidemiologic studies have found evidence of an inverse association between diabetes status and prostate cancer risk. We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer.Methods
We tested 17 diabetes risk variants for association with prostate cancer risk in a prostate cancer case-control study of 2,746 cases and 3,317 controls from five racial/ethnic groups in the Multiethnic Cohort (MEC) study.Results
After adjustment for multiple testing, none of the alleles were statistically significantly associated with prostate cancer risk. Aggregate scores that sum the risk alleles were also not significantly associated with risk.Conclusions
We did not find evidence of association of this set of diabetes risk alleles with prostate cancer.Impact
Resequencing and fine-mapping of the loci for diabetes and prostate cancer that were identified by genome-wide association studies are necessary to understand any genetic contribution for the inverse association between these common diseases.
SUBMITTER: Waters KM
PROVIDER: S-EPMC3175821 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110712 9
<h4>Background</h4>Epidemiologic studies have found evidence of an inverse association between diabetes status and prostate cancer risk. We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer.<h4>Methods</h4>We tested 17 diabetes risk variants for association with prostate cancer risk in a prostate cancer case-control study of 2,746 cases and 3,317 controls from five racial/ethnic groups in the Multiethnic Cohor ...[more]