Ontology highlight
ABSTRACT:
SUBMITTER: Prabakaran T
PROVIDER: S-EPMC3176300 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Prabakaran Thaneas T Nielsen Rikke R Larsen Jakob V JV Sørensen Søren S SS Feldt-Rasmussen Ulla U Saleem Moin A MA Petersen Claus M CM Verroust Pierre J PJ Christensen Erik I EI
PloS one 20110919 9
Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide. This study identifies in the human podocyte three endocytic receptors, mannose 6-phosphate/insulin-like growth II receptor, megalin, and sortilin and demonstrates their drug delivery capabilities for enzyme replacement therapy. Sortilin, a novel α-galactosida ...[more]