Ontology highlight
ABSTRACT:
SUBMITTER: Richards J
PROVIDER: S-EPMC3176438 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Richards Jamie J Liu Quansheng Q Pellegrini Olivier O Celesnik Helena H Yao Shiyi S Bechhofer David H DH Condon Ciarán C Belasco Joel G JG
Molecular cell 20110901 6
In Escherichia coli, RNA degradation often begins with conversion of the 5'-terminal triphosphate to a monophosphate, creating a better substrate for internal cleavage by RNase E. Remarkably, no homolog of this key endonuclease is present in many bacterial species, such as Bacillus subtilis and various pathogens. Here, we report that the degradation of primary transcripts in B. subtilis can nevertheless be triggered by an analogous process to generate a short-lived, monophosphorylated intermedia ...[more]