Transcription initiation from within P elements generates hypomorphic mutations in Drosophila melanogaster.
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ABSTRACT:
SUBMITTER: LaFave MC
PROVIDER: S-EPMC3176530 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Transcription initiation from within P elements generates hypomorphic mutations in Drosophila melanogaster.
LaFave Matthew C MC Sekelsky Jeff J
Genetics 20110428 3
Numerous transposable element insertions in Drosophila melanogaster cause hypomorphic mutations. We report that transcription initiation within a region found in many P-element constructs provides an explanation for why some gene function is retained. We detected evidence of this transcription in four different types of P constructs, regardless of whether the insertion was in a coding exon, intron, 5' untranslated region, or upstream of the gene span. ...[more]
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