Dataset Information

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

ABSTRACT:

Objective

To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele.

Design

Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies.

Setting

An international ovarian cancer consortium including studies from Australia, Europe, and the United States.

Patient(s)

Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies.

Intervention(s)

None.

Main outcome measure(s)

Genotypes for the +331C/T single nucleotide polymorphism and PROGINS allele and a history of endometriosis.

Result(s)

The occurrence of endometriosis was reduced in women carrying one or more copies of the +331 T allele (odds ratio=0.65; 95% confidence interval: 0.43-0.98), whereas there was no association between the PROGINS allele and endometriosis (odds ratio=0.94, 95% confidence interval 0.76-1.16).

Conclusion(s)

Additional studies of the +331C/T variant are warranted given the current finding and the equivocal results of previous studies. The +331 T allele has been shown to result in a reduced progesterone (P) receptor A to P receptor B ratio, and if the observed association with endometriosis is confirmed it would suggest that this ratio is important for this disease.

SUBMITTER: Near AM

PROVIDER: S-EPMC3176720 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

Near Aimee M AM Wu Anna H AH Templeman Claire C Van Den Berg David J DJ Doherty Jennifer A JA Rossing Mary Anne MA Goode Ellen L EL Cunningham Julie M JM Vierkant Robert A RA Fridley Brooke L BL Chenevix-Trench Georgia G Webb Penelope M PM Kjær Susanne Krüger SK Hogdall Estrid E Gayther Simon A SA Ramus Susan J SJ Menon Usha U Gentry-Maharaj Aleksandra A Schildkraut Joellen M JM Moorman Patricia G PG Palmieri Rachel T RT Ness Roberta B RB Moysich Kirsten K Cramer Daniel W DW Terry Kathryn L KL Vitonis Allison F AF Pike Malcolm C MC Berchuck Andrew A Pearce Celeste Leigh CL

Fertility and sterility 20100817 1

<h4>Objective</h4>To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele.<h4>Design</h4>Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies.<h4>Setting</h4>An international ovarian cancer consortium including studies from Australia, Europe, and ...[more]

PMID: 20719308

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Dataset Information

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

Objective

Design

Setting

Patient(s)

Intervention(s)

Main outcome measure(s)

Result(s)

Conclusion(s)

Publications

Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

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